Iron Accumulation, Brain Shrinkage, and Cognitive Aging
This project investigates longitudinal associations among subcortical iron accumulation, brain shrinkage, and fluid intelligence decline using four waves of MRI and cognitive data spanning approximately eight years.
Research Questions
- Does iron accumulation precede brain shrinkage?
- Does brain shrinkage contribute to cognitive decline?
- How are iron, brain structure, and cognition linked across aging?